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We examine how R&D portfolios of drug pipelines affect pharmaceutical licensing, controlling firm size, diversity, and competition. The data collected comprises 434 license-ins and 329 license-outs closed by 54 Japanese pharmaceutical companies between 1997 and 2007. We pay special attention to stage-specific licensing by dividing the innovation process into early and late stages. Joint estimates of license-in and license-out using seemingly unrelated regressions (SUR) reveal that drug pipelines significantly affect stage-specific licensing, inducing portfolio effect that lead to smoothing drug pipelines across early and late stages. 相似文献
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Bryan James Moseley Yukari Okamoto Junichi Ishida 《International Journal of Science and Mathematics Education》2007,5(1):165-185
Using cognitive ethnography as a guiding framework, we investigated US and Japanese fourth-grade teachers' domain knowledge
of key fraction representations in individual interviews. The framework focused on revealing cultural trends in participants'
organization of knowledge and their interpretations of that organization. Our analyses of the interviews, which included a
representation sorting task, indicated three major differences that defined US and Japanese teachers' approaches to rational
number representation: (1) Japanese teachers interpreted all rational number representations as conveying primarily mathematical
information, whereas US teachers interpreted only some representations as conveying primarily mathematical information; (2)
the US teachers focused more intently on part-whole relations than Japanese in their interpretations; and (3) Japanese teachers
more easily linked rational number representations to more advanced upcoming content in the curriculum. A review of US textbooks
used by the teachers reflected their consistency with US teachers' interpretations of the representations. These findings
imply that strong cultural differences underlay the approaches that teachers in both nations take to rational number representation
and that these differences may help explain established cross-national differences in student reasoning. 相似文献
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Industrial clusters have attracted considerable attention worldwide for their expected contribution to regional innovation. Recently, policymakers in various countries have developed specific cluster policies. However, there exist few empirical studies on cluster policies. Focusing on the Industrial Cluster Project (ICP) in Japan initiated by the Ministry of Economy, Trade and Industry in 2001, we address two research questions on the support programs of the cluster policies: if the project participants who exploit various support programs are more successful in network formation within the cluster than others, and which kind of support program contributes to firm performance. We pay special attention to the differences between direct R&D support and indirect networking/coordination support. The estimation results, which are based on recent original survey data, suggest that cluster participants who exploit support programs (especially indirect support measures) expand the industry-university-government network after participating in the ICP. Moreover, we find that not every support program contributes to firm performance; firms should therefore select the program that is most aligned with their aims. Indirect support programs have an extensive and strong impact on output whereas direct R&D support has only a weak effect. 相似文献
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In design phases, expansion joints are required to have movement capacity, bearing capacity for static and dynamic loading, watertight, low noise emission and traffic safety. On the basis of the fact that failure due to dynamic loading is the main reason for the observed damages, attention is focused on the bearing capacity for dynamic loading governed by impact, because it differs from the static loading. In this study, from the viewpoint of durability, experimental studies for dynamic behavior were conducted for aluminium alloy expansion joints with perforated dowels. The validity of the perforated dowels against traffic impact loading was confirmed by both experimental and numerical studies. 相似文献
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Junichi Hasegawa 《Educational Studies in Mathematics》1997,32(2):157-179
In order to understand the concept of an n-gon it can be characterized by a commutative diagram which is composed of four ways of judging a given figure as an n-gon, and it is examined through some cases on the introductory instruction on the concept of triangles and quadrilaterals. In each of these cases, it was observed that some children gave persuading arguments containing a critical idea and the concept formation corresponded to a structure-preserved transformation in the diagram. Following the diagram, four stages on the concept formation and its development are introduced. According to two operations in the diagram, essentially two kinds of teaching tools can be distinguished. Putting these issues together, an experimental instruction is designed and implemented. 相似文献
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R&D consortia have been regarded as an effective means of promoting innovation. Several R&D consortia obtain public financial support, which may affect their governance structure and performance. This study investigates the governance mechanisms of publicly funded R&D consortia and their effects on innovation performance. Few studies have empirically addressed the effect of project monitoring by the government or the role of project leadership in R&D consortia. Focusing on a major support program for R&D consortia in Japan and using a sample of 251 firms that participated in publicly funded R&D consortia from 2004 to 2009, we empirically confirm that to enhance firms’ innovation performance, both project leadership as internal discipline and government monitoring as external discipline matter. Our results show that project leadership directly improves firms’ innovation performance, while firms’ commitment indirectly affects performance. Project leadership and government monitoring also promote commitment. Furthermore, both factors are complementary: consortia members are more willing to accept a project leader’s coordination under stricter government monitoring. 相似文献
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How do new industries emerge? This paper aims to answer this question by analyzing the key actors in this process. We focus on the new industry of service robot. By using data of Japanese patent applications, we analyze the role of new firms and of collaborations. We find that the emergence of the industry is mainly triggered by established large firms, rather than by new firms. We further show that collaborations are at the core of new industry formation, but that they possess distinct properties. As the emergence of this new industry matches to the characteristics of Japan's institutional and knowledge regime we essentially argue that the notion of regimes with fewer start-ups being inefficient is erroneous. Our main conclusion is that industry emergence in intrapreneurial regimes seems to be distinctive from entrepreneurial regimes. 相似文献
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Abstract The present study aimed to quantify the intensity of lower extremity plyometric exercises by determining joint mechanical output. Ten men (age, 27.3 ± 4.1 years; height, 173.6 ± 5.4 cm; weight, 69.4 ± 6.0 kg; 1-repetition maximum [1RM] load in back squat 118.5 ± 12.0 kg) performed the following seven plyometric exercises: two-foot ankle hop, repeated squat jump, double-leg hop, depth jumps from 30 and 60 cm, and single-leg and double-leg tuck jumps. Mechanical output variables (torque, angular impulse, power, and work) at the lower limb joints were determined using inverse-dynamics analysis. For all measured variables, ANOVA revealed significant main effects of exercise type for all joints (P < 0.05) along with significant interactions between joint and exercise (P < 0.01), indicating that the influence of exercise type on mechanical output varied among joints. Paired comparisons revealed that there were marked differences in mechanical output at the ankle and hip joints; most of the variables at the ankle joint were greatest for two-foot ankle hop and tuck jumps, while most hip joint variables were greatest for repeated squat jump or double-leg hop. The present results indicate the necessity for determining mechanical output for each joint when evaluating the intensity of plyometric exercises. 相似文献
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